Nature Reviews Neuroscience: Neuroinflammatory and neurodegenerative disorders — as well as normal ageing — are accompanied by changes in endocannabinoid signalling. In this Review, Di Marzo and colleagues discuss the different mechanisms through which endocannabinoid signalling both contributes to and mitigates these conditions, and how they could serve as targets for novel therapeutics. http://bit.ly/1AqbEIs (£)